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JUN

JUN,全名為Jun原癌基因,AP-1轉(zhuǎn)錄因子亞單位,也被稱為c-Jun。它在細(xì)胞內(nèi)作為轉(zhuǎn)錄因子,參與調(diào)控基因表達(dá)。JUN蛋白在多種生理和病理過程中扮演重要角色,如細(xì)胞增殖、分化和凋亡。與AP-1復(fù)合物結(jié)合后,JUN蛋白能夠激活或抑制特定基因的轉(zhuǎn)錄,從而影響細(xì)胞的生命活動(dòng)。JUN蛋白的異常表達(dá)與多種疾病相關(guān),包括癌癥、炎癥和自身免疫疾病。近年來,針對(duì)JUN蛋白及其相關(guān)信號(hào)通路的研究不斷深入,為開發(fā)新型藥物提供了新的思路。

熱銷產(chǎn)品

Recombinant Human Transcription factor Jun (JUN) (CSB-BP011972HU)

驗(yàn)證數(shù)據(jù)

CSB-BP011972HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

JUN Recombinant Monoclonal Antibody (CSB-RA911286A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA911286A0HU

Western Blot
Positive WB detected in: 293 whole cell lysate
All lanes: JUN antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36 kDa
Observed band size: 43 kDa

CSB-RA911286A0HU

IHC image of CSB-RA911286A0HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

JUN Antibodies

JUN for Homo sapiens (Human)

JUN Proteins

JUN Proteins for Rattus norvegicus (Rat)

JUN Proteins for Gallus gallus (Chicken)

JUN Proteins for Sus scrofa (Pig)

JUN Proteins for Homo sapiens (Human)

JUN Proteins for Mus musculus (Mouse)

JUN Proteins for Bos taurus (Bovine)

JUN Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

JUN Proteins for Serinus canaria (Island canary) (Fringilla canaria)

JUN Proteins for Avian sarcoma virus (strain 17)