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LRP2

Low-density lipoprotein receptor-related protein 2 is a protein in humans that is encoded by LRP2 gene. Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity).

LRP2 Antibodies

LRP2 for Homo sapiens (Human)

LRP2 Proteins

LRP2 Proteins for Homo sapiens (Human)

LRP2 Proteins for Rattus norvegicus (Rat)

LRP2 Proteins for Mus musculus (Mouse)