MIF

MIF，全稱為巨噬細胞遷移抑制因子，是一種具有促炎和趨化特性的細胞因子，也被稱為MIF-1。它由多種免疫和非免疫細胞分泌，參與炎癥、自身免疫和腫瘤等多種病理過程。MIF通過與CD74、CXCR2、CXCR4等受體結合，形成復雜信號網絡并介導多樣生物學效應。MIF在先天免疫系統中居于核心地位，其獨特的糖皮質激素抗炎作用的內源性反調節因子特性，使其在免疫平衡中發揮重要作用。MIF在多種癌癥中表現出促腫瘤活性，通過促進細胞增殖、遷移及免疫微環境，系統性促進腫瘤發生發展。此外，MIF還參與類風濕關節炎、哮喘及重癥肌無力等自身免疫性疾病，以及急性肝損傷、慢性腎病等炎癥性疾病。目前，針對MIF的藥物研發呈現多樣化趨勢，包括小分子化藥、抗體、PROTAC、基因治療等多種類型，已在腫瘤、炎癥性疾病、神經退行性疾病、纖維化等多個領域進行探索。其中，艾美斐生物的IPG1094片作為全球首個靶向巨噬細胞移動抑制因子(MIF)的小分子抑制劑，在臨床前研究中顯示對多種實體腫瘤、多發性骨髓瘤以及自身免疫性疾病具有良好治療作用，并已獲得國家藥監局批準用于治療實體瘤和多發性骨髓瘤。

熱銷產品

Recombinant Human Macrophage migration inhibitory factor (MIF) (Active) (CSB-MP013826HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized MIF at 2 μg/ml can bind Anti- MIF Rabbit Monoclonal Antibody(CSB-RA146975A0HU), the EC₅₀ is 49.61-69.45 ng/ml.

MIF Antibody

MIF Protein

MIF ELISA Kit

MIF Antibodies

MIF for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA06867A0Rb	MIF Antibody	Human, Rat, Mouse	ELISA, WB, IHC, IF
CSB-PA06867B0Rb	MIF Antibody, HRP conjugated	Human	ELISA
CSB-PA06867D0Rb	MIF Antibody, Biotin conjugated	Human	ELISA
CSB-PA013826GA01HU	MIF Antibody	Human,Mouse	ELISA,WB
CSB-PA003240	MIF Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA010192	MIF Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-RA146975A0HU	MIF Recombinant Monoclonal Antibody	Human	ELISA, WB
CSB-RA013826MA1HU	MIF Recombinant Monoclonal Antibody	Human	ELISA, IF, FC

MIF for Mus musculus (Mouse)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA013826LA01MO	Mif Antibody	Mouse	ELISA, WB
CSB-PA013826LB01MO	Mif Antibody,HRP conjugated	Mouse	ELISA
CSB-PA013826LC01MO	Mif Antibody，FITC conjugated	Mouse
CSB-PA013826LD01MO	Mif Antibody，Biotin conjugated	Mouse	ELISA

MIF Proteins

MIF Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP013826PI CSB-EP013826PI CSB-BP013826PI CSB-MP013826PI CSB-EP013826PI-B	Recombinant Pig Macrophage migration inhibitory factor (MIF)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP013826BO CSB-EP013826BO CSB-BP013826BO CSB-MP013826BO CSB-EP013826BO-B	Recombinant Bovine Macrophage migration inhibitory factor (MIF)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP013826HU	Recombinant Human Macrophage migration inhibitory factor (MIF)	Yeast
CSB-EP013826HUa0	Recombinant Human Macrophage migration inhibitory factor (MIF)	E.coli
CSB-AP000281HU	Recombinant Human Macrophage migration inhibitory factor protein (MIF)	E.Coli
CSB-AP000291HU	Recombinant Human Macrophage migration inhibitory factor protein (MIF)	E.Coli
CSB-EP013826HU	Recombinant Human Macrophage migration inhibitory factor (MIF)	E.coli
CSB-BP013826HU	Recombinant Human Macrophage migration inhibitory factor (MIF)	Baculovirus
CSB-MP013826HU	Recombinant Human Macrophage migration inhibitory factor (MIF) (Active)	Mammalian cell

MIF Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP013826MO	Recombinant Mouse Macrophage migration inhibitory factor (Mif)	Yeast
CSB-AP000501MO	Recombinant Mouse Macrophage migration inhibitory factor protein (Mif)	E.Coli
CSB-EP013826MO	Recombinant Mouse Macrophage migration inhibitory factor (Mif)	E.coli
CSB-BP013826MO CSB-MP013826MO CSB-EP013826MO-B	Recombinant Mouse Macrophage migration inhibitory factor (Mif)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP013826RA CSB-EP013826RA CSB-BP013826RA CSB-MP013826RA CSB-EP013826RA-B	Recombinant Rat Macrophage migration inhibitory factor (Mif)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

產品貨號	產品名稱	來源
CSB-YP013826XBF CSB-EP013826XBF CSB-BP013826XBF CSB-MP013826XBF CSB-EP013826XBF-B	Recombinant Xenopus tropicalis Macrophage migration inhibitory factor (mif)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

產品貨號	產品名稱	來源
CSB-YP013826MRA CSB-EP013826MRA CSB-BP013826MRA CSB-MP013826MRA CSB-EP013826MRA-B	Recombinant Meriones unguiculatus Macrophage migration inhibitory factor (MIF)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Wuchereria bancrofti

產品貨號	產品名稱	來源
CSB-YP526135WBS CSB-EP526135WBS CSB-BP526135WBS CSB-MP526135WBS CSB-EP526135WBS-B	Recombinant Macrophage migration inhibitory factor homolog (MIF)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Ovis aries (Sheep)

產品貨號	產品名稱	來源
CSB-YP638543SH CSB-EP638543SH CSB-BP638543SH CSB-MP638543SH CSB-EP638543SH-B	Recombinant Sheep Macrophage migration inhibitory factor (MIF)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產品貨號	產品名稱	來源
CSB-YP686998MOV CSB-EP686998MOV CSB-BP686998MOV CSB-MP686998MOV CSB-EP686998MOV-B	Recombinant Macaca fascicularis Macrophage migration inhibitory factor (MIF)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Macaca mulatta (Rhesus macaque)

產品貨號	產品名稱	來源
CSB-YP732254MOW CSB-EP732254MOW CSB-BP732254MOW CSB-MP732254MOW CSB-EP732254MOW-B	Recombinant Macaca mulatta Macrophage migration inhibitory factor (MIF)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MIF Proteins for Xenopus laevis (African clawed frog)

產品貨號	產品名稱	來源
CSB-YP751850XBE CSB-EP751850XBE CSB-BP751850XBE CSB-MP751850XBE CSB-EP751850XBE-B	Recombinant Xenopus laevis Macrophage migration inhibitory factor (mif)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli