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MORC3

MORC3,即微管組織蛋白,別名KIAA0136、ZCWCC3、NXP2。它是一種核基質蛋白,具有核基質結合結構域,含有推定的RNA結合位點,對轉錄調控至關重要。MORC3在免疫細胞中的表達水平較高,且在化療后正常外周血白細胞中的表達明顯上調,表明它可能參與調節細胞存活與細胞凋亡。MORC3通過激活p53并將其定位于早幼粒細胞白血病(PML)核體內,誘導p53依賴的細胞衰老。此外,MORC3還參與DNA損傷修復和表觀遺傳調控,其異常表達與癌癥、自身免疫疾病和骨病相關。MORC3的功能區圖譜揭示了它在多種基本生物學過程中的作用,包括信號依賴的染色質重塑和表觀遺傳調控,促進脂肪生成,參與癌癥發生和骨穩態調節。

熱銷產品

Recombinant Human MORC family CW-type zinc finger protein 3 (MORC3), partial (CSB-EP622753HU)

驗證數據

CSB-EP622753HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP622753HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP622753HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MORC3.

CSB-EP622753HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP622753HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MORC3.

MORC3 Proteins

MORC3 Proteins for Homo sapiens (Human)