MUC13

MUC13（黏蛋白13）是一種高分子量的跨膜糖蛋白，通常在胃腸道和呼吸道上皮細(xì)胞表達(dá)，具有保護(hù)和潤滑黏膜上皮的功能。它由α、β兩個亞基組成，包含N末端信號肽、串聯(lián)重復(fù)序列（TR）結(jié)構(gòu)域和SEA結(jié)構(gòu)域，MUC13基因包含12個外顯子，編碼511個氨基酸。MUC13通過促進(jìn)細(xì)胞增殖和遷移、抑制細(xì)胞凋亡和降低細(xì)胞黏附來參與多種病理過程。它在炎癥調(diào)節(jié)和腫瘤發(fā)展中扮演重要角色，特別是在多種上皮性腫瘤中，如胃癌、結(jié)直腸癌和卵巢癌，MUC13的異常表達(dá)已被廣泛觀察到。MUC13通過激活包括EGFR/PI3K/AKT、Wnt和NF-κB在內(nèi)的信號通路，影響腫瘤細(xì)胞的增殖、侵襲和存活。由于其在腫瘤發(fā)展中的潛在作用，MUC13被認(rèn)為是腫瘤早期診斷和治療的有希望的靶點，其研究有助于開發(fā)新的癌癥治療策略。

熱銷產(chǎn)品

Recombinant Human Mucin-13(MUC13),partial (Active) (CSB-YP887973HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MUC13 at 2 μg/ml can bind Anti-MUC13 recombinant antibody (CSB-RA887973MA1HU). The EC₅₀ is 2.592-2.923 ng/mL.

MUC13 Antibody

MUC13 Protein

MUC13 Antibodies

MUC13 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA276815	MUC13 Antibody	Human	ELISA,WB,IHC,IF
CSB-PA003335	MUC13 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA237856	MUC13 Antibody	Human	ELISA,IHC
CSB-PA131838	MUC13 Antibody	Human	ELISA,IHC

MUC13 Proteins

MUC13 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-EP887973HU CSB-BP887973HU CSB-EP887973HU-B	Recombinant Human Mucin-13 (MUC13), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-YP887973HU	Recombinant Human Mucin-13(MUC13),partial (Active)	yeast
CSB-MP887973HU	Recombinant Human Mucin-13(MUC13),partial (Active)	Mammalian cell