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NEFL

神經(jīng)纖維絲輕鏈(NEFL)是神經(jīng)元軸突的主要細(xì)胞骨架蛋白,對(duì)維持神經(jīng)元形態(tài)和信號(hào)傳導(dǎo)至關(guān)重要。正常生理?xiàng)l件下,軸突釋放少量NEFL,但在病理?xiàng)l件下,其釋放量顯著增加。組織液中的NEFL可通過(guò)腦脊液擴(kuò)散至血液,血液中NEFL濃度較腦脊液低,且與神經(jīng)病變程度密切相關(guān),因此NEFL被用作神經(jīng)元損傷相關(guān)疾病的生物標(biāo)志物。在阿爾茨海默病、帕金森病、肌萎縮側(cè)索硬化癥等神經(jīng)退行性疾病中,血液中的NEFL水平都會(huì)上升。此外,NEFL水平也隨年齡增長(zhǎng)而上升,可作為疾病診斷和預(yù)后監(jiān)測(cè)的指標(biāo)。目前,針對(duì)NEFL的藥物研發(fā)尚處于早期階段,但其在神經(jīng)疾病診斷和監(jiān)測(cè)中的應(yīng)用前景廣闊。

熱銷(xiāo)產(chǎn)品

Recombinant Human Neurofilament light polypeptide (NEFL) (CSB-CF015688HU)

驗(yàn)證數(shù)據(jù)

CSB-CF015688HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NEFL Antibody (CSB-PA015688LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA015688LA01HU

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015688LA01HU at dilution of 1:100

CSB-PA015688LA01HU

Immunofluorescent analysis of SH-SY5Y cells using CSB-PA015688LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CSB-PA015688LA01HU

Immunoprecipitating NEFL in mouse brain tissue
Lane 1: Rabbit control IgG instead of CSB-PA015688LA01HU in mouse brain tissue. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA015688LA01HU (8μg) + Mouse brain tissue (500μg)
Lane 3: Mouse brain tissue (10μg)

Human Neurofilament protein L (NF-L) ELISA kit (CSB-E16094h)

驗(yàn)證數(shù)據(jù)

CSB-E16094h 標(biāo)準(zhǔn)曲線(xiàn)

貨號(hào):CSB-E16094h

規(guī)格:96T/48T

靈敏度:7.8 pg/mL

檢測(cè)范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

NEFL Antibodies

NEFL for Homo sapiens (Human)

NEFL Proteins

NEFL Proteins for Mus musculus (Mouse)

NEFL Proteins for Homo sapiens (Human)

NEFL Proteins for Pongo abelii (Sumatran orangutan)

NEFL Proteins for Homo sapiens(Human)

NEFL Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

NEFL ELISA Kit

NEFL ELISA Kit for Homo sapiens (Human)