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PSENEN

PSENEN,全稱為早老素增強子γ-分泌酶亞基(Presenilin enhancer gamma-secretase subunit),別名PEN-2、MDS033。PSENEN是γ-分泌酶復合體的核心組成之一,與早老素(PSEN1/PSEN2)、APH-1等蛋白共同參與跨膜蛋白的切割過程,例如淀粉樣前體蛋白(APP)經(jīng)其剪切后產(chǎn)生β淀粉樣蛋白,這類蛋白異常沉積與阿爾茨海默病的病理特征密切相關(guān)。PSENEN通過調(diào)控Notch受體的活化影響細胞分化與發(fā)育,其功能異常可能引發(fā)家族性黑蒙癡呆等罕見遺傳病。近年來研究發(fā)現(xiàn),PSENEN基因突變還與某些皮膚腫瘤的發(fā)生相關(guān)。在藥物研發(fā)領(lǐng)域,針對γ-分泌酶復合體的抑制劑(如Semagacestat)曾進入阿爾茨海默病臨床試驗,但因干擾Notch通路引發(fā)嚴重副作用而終止。目前研究轉(zhuǎn)向開發(fā)選擇性調(diào)節(jié)劑,試圖在減少β淀粉樣蛋白生成的同時保留Notch信號功能,相關(guān)化合物如Nirogacestat已在乳腺癌和硬纖維瘤領(lǐng)域開展II期試驗。

熱銷產(chǎn)品

Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN) (CSB-CF878932HU)

驗證數(shù)據(jù)

CSB-CF878932HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PSENEN Antibody (CSB-PA878932OA01HU)

驗證數(shù)據(jù)

CSB-PA878932OA01HU

IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA878932OA01HU

IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

PSENEN Antibodies

PSENEN for Homo sapiens (Human)

PSENEN Proteins

PSENEN Proteins for Bos taurus (Bovine)

PSENEN Proteins for Dictyostelium discoideum (Slime mold)

PSENEN Proteins for Rattus norvegicus (Rat)

PSENEN Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

PSENEN Proteins for Mus musculus (Mouse)

PSENEN Proteins for Homo sapiens (Human)