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PYY

PYY,即肽YY,別名PYY3-36(指其C末端的36個(gè)氨基酸片段)。它是一種由腸道L細(xì)胞分泌的多肽激素,屬于胰高血糖素樣肽(GLP)家族成員,與GLP-1具有高度同源性。PYY在人體中由PYY基因編碼,主要在腸道內(nèi)分泌細(xì)胞產(chǎn)生,尤其是回腸和結(jié)腸。PYY的作用機(jī)制主要通過與其特異性G蛋白偶聯(lián)受體NPY Y2受體(Y2R)和NPY Y4受體(Y4R)結(jié)合來發(fā)揮作用。PYY3-36片段是PYY的活性形式,它在腸道分泌后進(jìn)入血液循環(huán),通過與Y2R結(jié)合,減緩胃排空速度,抑制食欲,從而減少食物攝入。此外,PYY還能通過影響腸道運(yùn)動(dòng)和分泌,參與調(diào)節(jié)腸道功能。PYY在生物學(xué)上的意義非常廣泛,它在能量平衡、體重調(diào)節(jié)、胰島素分泌和腸道穩(wěn)態(tài)中發(fā)揮重要作用。PYY通過減緩胃排空,增強(qiáng)飽腹感,有助于減少食物攝入和控制體重。在糖尿病治療中,PYY3-36通過促進(jìn)胰島素和抑制胰高血糖素的分泌,有助于改善血糖控制。此外,PYY還參與調(diào)節(jié)腸道屏障功能和炎癥反應(yīng),對腸道健康具有保護(hù)作用。因此,PYY是代謝和消化系統(tǒng)研究中的一個(gè)重要分子,也是治療肥胖癥和糖尿病的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Peptide YY (PYY), partial (CSB-YP019128HU1)

驗(yàn)證數(shù)據(jù)

CSB-YP019128HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PYY Antibody (CSB-PA12214A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA12214A0Rb

IHC image of CSB-PA12214A0Rb diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA12214A0Rb

IHC image of CSB-PA12214A0Rb diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Rat Polypeptide YY(PYY)ELISA Kit (CSB-E13432r)

驗(yàn)證數(shù)據(jù)

CSB-E13432r 標(biāo)準(zhǔn)曲線

貨號:CSB-E13432r

規(guī)格:96T/48T

靈敏度:1.95 pg/mL

檢測范圍:7.8 pg/mL-500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PYY Antibodies

PYY for Homo sapiens (Human)

PYY Proteins

PYY Proteins for Homo sapiens (Human)

PYY ELISA Kit

PYY ELISA Kit for Homo sapiens (Human)