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S100A4

S100A4蛋白全稱為鈣結合蛋白S100A4,也被稱為轉移素或p9Ka,是一種多功能小分子蛋白。它通過與細胞內(nèi)不同靶點結合,影響細胞骨架動態(tài)變化,促進細胞運動及侵襲能力,尤其在腫瘤轉移過程中扮演關鍵角色。S100A4常與乳腺癌、結直腸癌等多種惡性腫瘤的侵襲性生長和遠端擴散密切相關,其高表達常提示患者預后不良。此外,在肺纖維化、類風濕性關節(jié)炎等慢性疾病中,S100A4也被發(fā)現(xiàn)參與組織異常重塑和炎癥反應調(diào)控。
近年來研究發(fā)現(xiàn),抑制S100A4功能可有效減緩腫瘤轉移進程。多個研究團隊正在開發(fā)針對該蛋白的小分子抑制劑和單克隆抗體,其中部分化合物已在動物模型中顯示出阻斷癌細胞遷移的效果。某些已上市藥物如二甲雙胍被發(fā)現(xiàn)具有間接調(diào)控S100A4表達的作用,這為老藥新用提供了潛在方向。學術界與制藥企業(yè)正通過結構生物學手段解析其三維構象,以期設計出更精準的靶向治療藥物。

熱銷產(chǎn)品

Recombinant Human Protein S100-A4 (S100A4) (CSB-EP020632HU)

驗證數(shù)據(jù)

CSB-EP020632HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

S100A4 Antibody (CSB-PA020632HA01HU)

驗證數(shù)據(jù)

CSB-PA020632HA01HU

Western blot
All lanes: S100A4 antibody at 2µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa

CSB-PA020632HA01HU

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA020632HA01HU

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

S100A4 Antibodies

S100A4 for Homo sapiens (Human)

S100A4 Proteins

S100A4 Proteins for Homo sapiens (Human)

S100A4 Proteins for Bos taurus (Bovine)

S100A4 Proteins for Rattus norvegicus (Rat)

S100A4 Proteins for Mus musculus (Mouse)

S100A4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

S100A4 ELISA Kit

S100A4 ELISA Kit for Homo sapiens (Human)

S100A4 ELISA Kit for Mus musculus (Mouse)



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