SARM1
SARM1，全稱為含無菌α和TIR基序的蛋白1，常被簡稱為SARM。它是人體神經(jīng)細(xì)胞內(nèi)調(diào)控軸突退變的關(guān)鍵分子，當(dāng)神經(jīng)纖維受損傷、缺血或代謝應(yīng)激時(shí)，SARM1會(huì)被激活，啟動(dòng)一系列反應(yīng)導(dǎo)致軸突結(jié)構(gòu)破壞甚至神經(jīng)細(xì)胞死亡。這種激活過程與漸凍癥（ALS）、多發(fā)性硬化癥、糖尿病性周圍神經(jīng)病變等多種神經(jīng)系統(tǒng)疾病密切相關(guān)——在這些疾病患者的病變神經(jīng)組織中，常能檢測到SARM1活性升高，它可能加速神經(jīng)損傷的進(jìn)展。目前針對(duì)SARM1的藥物研發(fā)正穩(wěn)步推進(jìn)，多款抑制其活性的小分子候選藥物已進(jìn)入早期臨床試驗(yàn)階段，有望為這類難治性神經(jīng)疾病帶來新的治療希望。
熱銷產(chǎn)品
Recombinant Human NAD (+) hydrolase SARM1 (SARM1), partial (CSB-EP750971HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SARM1 Proteins
SARM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP750971HU CSB-EP750971HU-B |
Recombinant Human NAD (+) hydrolase SARM1 (SARM1) | Yeast In Vivo Biotinylation in E.coli |
| CSB-EP750971HU1 | Recombinant Human NAD (+) hydrolase SARM1 (SARM1), partial | E.coli |
| CSB-YP750971HU2 | Recombinant Human NAD (+) hydrolase SARM1 (SARM1), partial | Yeast |
| CSB-MP750971HU1 | Recombinant Human NAD(+) hydrolase SARM1 (SARM1), partial | Mammalian cell |
| CSB-MP750971HU | Recombinant Human NAD(+) hydrolase SARM1 (SARM1) | Mammalian cell |
| CSB-EP750971HU | Recombinant Human NAD(+) hydrolase SARM1 (SARM1) | E.coli |
SARM1 Proteins for Homo sapiens(Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP750971HU | Recombinant Human NAD (+) hydrolase SARM1 (SARM1) | Baculovirus |
