SINHCAF
SINHCAF，即SIN3-HDAC復(fù)合體相關(guān)因子，別名FAM60A、TERA。這是一種在人類細(xì)胞中發(fā)現(xiàn)的蛋白質(zhì)，參與調(diào)控基因表達(dá)。SINHCAF是組蛋白去乙酰化酶復(fù)合體的組分之一，通過與SIN3A和HDAC1等蛋白相互作用，促進(jìn)組蛋白去乙酰化，從而抑制基因的表達(dá)。在斑馬魚中，SINHCAF對于原始生殖細(xì)胞（PGC）的形成至關(guān)重要，其敲除會導(dǎo)致PGC數(shù)量減少，影響性別比例，而過表達(dá)則會增加PGC數(shù)量，并傾向于雌性。此外，SINHCAF還參與負(fù)向調(diào)控細(xì)胞遷移，是Sin3復(fù)合體的一部分，對維持胚胎干細(xì)胞的快速增殖潛力和防止過早的細(xì)胞系分化至關(guān)重要。這些功能表明SINHCAF在細(xì)胞命運決定和發(fā)育過程中扮演著重要角色。
熱銷產(chǎn)品
Recombinant Human SIN3-HDAC complex-associated factor (SINHCAF) (Active) (CSB-EP882059HUe0)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized LCN2 at 2 μg/ml can bind human SINHCAF, the EC50 of human SINHCAF protein is 31.54-38.59 μg/ml.
SINHCAF Antibodies
SINHCAF for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA882059LA01HU | FAM60A Antibody | Human | ELISA, IHC |
| CSB-PA882059LD01HU | FAM60A Antibody, Biotin conjugated | Human | ELISA |
SINHCAF Proteins
SINHCAF Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP882059HU CSB-EP882059HU CSB-BP882059HU CSB-MP882059HU CSB-EP882059HU-B |
Recombinant Human Protein FAM60A (FAM60A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP882059HUe0 | Recombinant Human SIN3-HDAC complex-associated factor (SINHCAF) (Active) | E.coli |
