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SLC2A1

SLC2A1全稱為葡萄糖轉運蛋白1(GLUT1),是人體內分布最廣的葡萄糖轉運載體,在血腦屏障、紅細胞和胎盤等組織中高表達。SLC2A1通過促進葡萄糖跨膜運輸維持腦部能量供應,對中樞神經系統功能至關重要。GLUT1缺陷綜合征是其最典型的遺傳性疾病,患者因轉運功能障礙出現嬰兒期癲癇、運動障礙和智力發育遲緩,臨床通過腦脊液葡萄糖檢測結合基因篩查確診,生酮飲食替代供能是目前主要干預手段。膠質母細胞瘤、乳腺癌等惡性腫瘤中GLUT1常異常高表達,與腫瘤代謝重編程密切相關,這使得SLC2A1成為抗癌藥物開發的重要靶點。例如小分子抑制劑BAY-876已在臨床前研究中顯示出阻斷腫瘤葡萄糖攝取的效果。研究人員正探索通過調控GLUT1活性改善糖尿病并發癥及阿爾茨海默病能量代謝障礙的新策略。

熱銷產品

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)-VLPs (Active) (CSB-MP021546HU(A4)d7)

驗證數據

CSB-MP021546HU(A4)d7

CSB-MP021546HU(A4)d7 is detected by Mouse anti-10*His monoclonal antibody.

CSB-MP021546HU(A4)d7

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SLC2A1 at 10 μg/ml can bind Anti-SLC2A1 recombinant antibody(CSB-RA021546MA1HU). The EC50 is 5.023-6.275 ng/mL.The VLPs (CSB-MP3838) is negative control.

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), partial (CSB-EP021546HU)

驗證數據

CSB-EP021546HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLC2A1 Recombinant Monoclonal Antibody (CSB-RA297401A0HU)

驗證數據

CSB-RA297401A0HU

IHC image of CSB-RA297401A0HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA297401A0HU

IHC image of CSB-RA297401A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

SLC2A1 Antibodies

SLC2A1 for Homo sapiens (Human)

SLC2A1 Proteins

SLC2A1 Proteins for Ovis aries (Sheep)

SLC2A1 Proteins for Homo sapiens (Human)

SLC2A1 Proteins for Oryctolagus cuniculus (Rabbit)

SLC2A1 Proteins for Sus scrofa (Pig)

SLC2A1 Proteins for Mus musculus (Mouse)

SLC2A1 Proteins for Bos taurus (Bovine)

SLC2A1 Proteins for Gallus gallus (Chicken)

SLC2A1 Proteins for Rattus norvegicus (Rat)



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