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SLC7A11

SLC7A11,即溶質載體家族7成員11,別名xCT、CCBR1。SLC7A11編碼的蛋白質是胱氨酸/谷氨酸反向轉運體(SystemXc-)的關鍵組成部分,主要負責將細胞外的胱氨酸運輸進細胞,以換取谷氨酸。這一過程對于維持細胞內谷胱甘肽(GSH)水平和保護細胞免受氧化應激誘導的細胞死亡至關重要。
SLC7A11不僅與細胞的營養依賴性和氧化應激反應有關,也是腫瘤治療的潛在靶點。SLC7A11在多種腫瘤中高表達,并與腫瘤的生長、預后、轉移與治療密切相關。SLC7A11的高表達增加了腫瘤細胞對氧化應激刺激的敏感性,并且可能通過抑制鐵死亡來促進腫瘤生長。

熱銷產品

Recombinant Human Cystine/glutamate transporter (SLC7A11) (Active) (CSB-CF892171HU(A4))

驗證數據

CSB-CF892171HU(A4)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-CF892171HU(A4)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SLC7A11 at 2μg/mL can bind Anti-SLC7A11 recombinant antibody (CSB-RA892171MA1HU), the EC50 is 9.452-13.79 ng/mL.

CSB-CF892171HU(A4)

Loaded Anti-Human SLC7A11 Antibody (CSB-RA892171MA1HU) on 96-Flat plate, can bind Human SLC7A11, with an affinity constant of <1 pM as determined in BLI assay (Gator Prime).

SLC7A11 Antibody (CSB-PA145393)

驗證數據

CSB-PA145393

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA145393(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA145393

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA145393(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA145393

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and hepg2 cell, Primary antibody: CSB-PA145393(SLC7A11 Antibody) at dilution 1/300 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds

SLC7A11 Antibodies

SLC7A11 for Homo sapiens (Human)

SLC7A11 Proteins

SLC7A11 Proteins for Pongo abelii (Sumatran orangutan)

SLC7A11 Proteins for Homo sapiens (Human)

SLC7A11 Proteins for Mus musculus (Mouse)