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SNCA

SNCA,全稱為α-突觸核蛋白(Alpha-synuclein),也被稱為NACP、PARK1、PARK4。這種蛋白主要在神經(jīng)元中表達(dá),參與調(diào)節(jié)突觸小泡的運(yùn)輸和神經(jīng)遞質(zhì)的釋放。α-突觸核蛋白的正常功能對于維持神經(jīng)系統(tǒng)的正常運(yùn)作至關(guān)重要。然而,當(dāng)其發(fā)生異常聚集時(shí),會(huì)形成路易小體和路易神經(jīng)纖維,這與帕金森病、路易體癡呆等多系統(tǒng)萎縮性神經(jīng)退行性疾病的發(fā)生發(fā)展密切相關(guān)。
近年來,針對α-突觸核蛋白的藥物研發(fā)取得了顯著進(jìn)展。例如,通過開發(fā)抗α-突觸核蛋白抗體藥物,可以干擾其聚集和病理傳播,從而治療帕金森病。此外,還有研究探索利用核酸藥物靶向α-突觸核蛋白基因,以降低其表達(dá)水平。這些研究成果為帕金森病等神經(jīng)退行性疾病的治療提供了新的希望。

熱銷產(chǎn)品

Recombinant Human Alpha-synuclein (SNCA), partial (CSB-EP021912HU1e1)

驗(yàn)證數(shù)據(jù)

CSB-EP021912HU1e1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SNCA Recombinant Monoclonal Antibody (CSB-RA021912MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA021912MA1HU

IHC image of CSB-RA021912MA1HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA021912MA1HU

IHC image of CSB-RA021912MA1HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA021912MA1HU

Immunofluorescence staining of SH-SY5Y cell with CSB-RA021912MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-RA021912MA1HU

Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA021912MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

SNCA Antibody (CSB-PA06994A0Rb)

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CSB-PA06994A0Rb

Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: SNCA antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 15 kDa
Observed band size: 15 kDa

CSB-PA06994A0Rb

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA06994A0Rb at dilution of 1:100

Human Alpha-synuclein (SNCA) ELISA Kit (CSB-E18033h)

驗(yàn)證數(shù)據(jù)

CSB-E18033h 標(biāo)準(zhǔn)曲線

貨號:CSB-E18033h

規(guī)格:96T/48T

靈敏度:0.078 ng/mL

檢測范圍:0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SNCA Antibodies

SNCA for Homo sapiens (Human)

SNCA for Rattus norvegicus (Rat)

SNCA Proteins

SNCA Proteins for Homo sapiens (Human)

SNCA Proteins for Rattus norvegicus (Rat)

SNCA Proteins for Mus musculus (Mouse)

SNCA Proteins for Sus scrofa (Pig)

SNCA Proteins for Serinus canaria (Island canary) (Fringilla canaria)

SNCA ELISA Kit

SNCA ELISA Kit for Homo sapiens (Human)

SNCA ELISA Kit for Rattus norvegicus (Rat)