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SRC

SRC,即肉瘤病毒蛋白Src,別名c-Src、p60-Src等。它是一種非受體酪氨酸激酶,屬于Src家族蛋白酪氨酸激酶成員,由人體細(xì)胞自身的SRC基因編碼。SRC在多種細(xì)胞類型中都有表達(dá),尤其在淋巴細(xì)胞和成骨細(xì)胞中表達(dá)較高。SRC的作用機(jī)制主要通過(guò)其激酶活性參與調(diào)節(jié)細(xì)胞內(nèi)的信號(hào)傳導(dǎo),它能夠磷酸化多種蛋白質(zhì)的酪氨酸殘基,從而激活或抑制這些蛋白質(zhì)的功能。SRC的活性受到多種因素的調(diào)控,包括磷酸化、去磷酸化、寡聚化和與膜的結(jié)合等。SRC在生物學(xué)上的意義非常廣泛,它參與了細(xì)胞的多種生理過(guò)程,包括細(xì)胞增殖、分化、遷移、黏附和凋亡等。SRC通過(guò)激活下游的多種信號(hào)通路,如MAPK、PI3K/AKT、JAK/STAT等,對(duì)細(xì)胞的生存和功能發(fā)揮重要作用。此外,SRC的功能異常與多種疾病的發(fā)生發(fā)展有關(guān),尤其是與腫瘤的發(fā)生、發(fā)展和轉(zhuǎn)移密切相關(guān)。在腫瘤細(xì)胞中,SRC的過(guò)度活化可以促進(jìn)腫瘤細(xì)胞的增殖和侵襲,使其成為腫瘤治療中的一個(gè)潛在靶點(diǎn)。因此,針對(duì)SRC的小分子抑制劑正在被開(kāi)發(fā)用于治療某些類型的癌癥。

熱銷產(chǎn)品

Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC) (CSB-EP022650HU)

驗(yàn)證數(shù)據(jù)

CSB-EP022650HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SRC Recombinant Monoclonal Antibody (CSB-RA022650A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA022650A0HU

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, MCF-7 whole cell lysate
All lanes: SRC antibody at 1.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60, 61 KDa
Observed band size: 60, 61 KDa

CSB-RA022650A0HU

Immunofluorescence staining of MCF-7 cells with CSB-RA022650A0HU at 1:39, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

CSB-RA022650A0HU

Overlay histogram showing SH-SY5Y cells stained with CSB-RA022650A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by primary antibody for 1 h at 4℃. The secondary antibody used was FITC goat anti-rabbit IgG (H+L) at 1/200 dilution for 1 h at 4℃. Control antibody (green line) was used under the same conditions. Acquisition of >10,000 events was performed.

Human Proto-oncogene tyrosine-protein kinase Src(SRC) ELISA kit (CSB-EL022650HU)

驗(yàn)證數(shù)據(jù)

CSB-EL022650HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL022650HU

規(guī)格:96T/48T

靈敏度:6.25 pg/mL

檢測(cè)范圍:25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SRC Antibodies

SRC for Homo sapiens (Human)

SRC for Danio rerio (Zebrafish) (Brachydanio rerio)

SRC Proteins

SRC Proteins for Homo sapiens (Human)

SRC Proteins for Mus musculus (Mouse)

SRC Proteins for Gallus gallus (Chicken)

SRC Proteins for Rattus norvegicus (Rat)

SRC ELISA Kit

SRC ELISA Kit for Homo sapiens (Human)