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TACSTD2

TACSTD2,即腫瘤相關鈣信號轉導子2,別名TROP2、EGP-1、GA733-1、M1S1等,由人類TACSTD2基因編碼,該基因位于1號染色體的1p32.1區域。TACSTD2蛋白是一種細胞表面糖蛋白,屬于單次跨膜蛋白,由323個氨基酸組成,具有一個疏水性前導肽、一個細胞外結構域、一個跨膜結構域和一個胞質尾部。
TACSTD2的作用機制涉及其胞質尾部的高度保守的磷脂酰肌醇4,5-二磷酸(PIP2)結合序列,該序列在信號轉導中起重要作用。TACSTD2通過與PIP2的相互作用以及酪氨酸和絲氨酸磷酸化位點參與細胞信號傳導,影響細胞周期進程。
TACSTD2在多種惡性腫瘤中過表達,與腫瘤的發生、侵襲和轉移有關,是一種重要的癌基因。TACSTD2的表達程度與疾病的惡性程度相關,其過表達可促進腫瘤細胞生長、增殖和轉移,故此成為了開發抗體偶聯藥物的新靶點。

熱銷產品

Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active) (CSB-MP023072HU1)

驗證數據

CSB-MP023072HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP023072HU1

Activity
Measured in cell activity assay using U937 cells, the EC50 for this effect is 190.2-298.6 ng/ml.

CSB-MP023072HU1

The purity of TACSTD2 was greater than 95% as determined by SEC-HPLC

TROP2 monoclonal antibody (CSB-RA023072MA1HU)

驗證數據

CSB-RA023072MA1HU

The Binding Activity of Huamn TROP2 with Anti-TROP2 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TROP2 (CSB-MP023072HU1d7) at 2 μg/mL can bind Anti-TROP2 recombinant antibody, the EC50 is 0.7284-1.075 ng/mL.

CSB-RA023072MA1HU

The Binding Activity of Huamn TROP2 with Anti-TROP2 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TROP2(CSB-MP023072HU2) at 2 μg/mL can bind Anti-TROP2 recombinant antibody, the EC50 is 0.9108-1.640 ng/mL.

CSB-RA023072MA1HU

The Binding Activity of Macaca fascicularit TROP2 with Anti-TROP2 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TACSTD2(CSB-MP6581MOV) at 2 μg/mL can bind Anti-TACSTD2 recombinant antibody The EC50 is 1.720-2.009 ng/mL.

TACSTD2 Antibodies

TACSTD2 for Homo sapiens (Human)

TACSTD2 Proteins

TACSTD2 Proteins for Rattus norvegicus (Rat)

TACSTD2 Proteins for Mus musculus (Mouse)

TACSTD2 Proteins for Homo sapiens (Human)



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