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THBS1

THBS1,即血栓素1,別名 THBS 1、THBS、Thbs1、Thrombospondin 1、Thrombospondin-1、TSP 1、TSP、TSP1。它是一種在多種細胞類型中表達的分泌型糖蛋白,由人體細胞自身的基因編碼。THBS1的作用機制涉及與多種細胞表面受體和細胞外基質(zhì)組分的相互作用,能夠調(diào)節(jié)細胞黏附、增殖、遷移和免疫反應(yīng)等過程。THBS1通過與CD36和CD47等受體結(jié)合,激活相關(guān)信號通路,影響腫瘤微環(huán)境中的免疫細胞活性和血管生成 。THBS1在腫瘤微環(huán)境中扮演著復(fù)雜的角色。它能夠抑制血管生成,調(diào)節(jié)抗腫瘤免疫反應(yīng),刺激腫瘤細胞遷移,并調(diào)節(jié)細胞外基質(zhì)中蛋白酶和生長因子的活性。THBS1的表達在多種腫瘤中發(fā)生改變,與腫瘤的侵襲性、轉(zhuǎn)移和治療抵抗性密切相關(guān)。例如,在結(jié)直腸癌中,THBS1的高表達與腫瘤的高侵襲性和免疫抑制密切相關(guān),其表達水平的升高與較差的預(yù)后相關(guān) 。因此,THBS1是腫瘤免疫治療和抗血管生成治療中的一個潛在靶點。

熱銷產(chǎn)品

Recombinant Human Thrombospondin-1 (THBS1), partial (CSB-RP073494h(N))

驗證數(shù)據(jù)

CSB-RP073494h(N)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

THBS1 Antibody (CSB-PA206082)

驗證數(shù)據(jù)

CSB-PA206082

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA206082(THBS1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA206082

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA206082(THBS1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA206082

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 cells, Huvec cells, Primary antibody: CSB-PA206082(THBS1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes

THBS1 Antibodies

THBS1 for Homo sapiens (Human)

THBS1 for Mus musculus (Mouse)

THBS1 Proteins

THBS1 Proteins for Homo sapiens (Human)

THBS1 Proteins for Xenopus laevis (African clawed frog)

THBS1 Proteins for Bos taurus (Bovine)

THBS1 ELISA Kit

THBS1 ELISA Kit for Homo sapiens (Human)

THBS1 ELISA Kit for Mus musculus (Mouse)



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