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TMEM30A

Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE).

TMEM30A Proteins

TMEM30A Proteins for Gallus gallus (Chicken)

TMEM30A Proteins for Rattus norvegicus (Rat)

TMEM30A Proteins for Pongo abelii (Sumatran orangutan)

TMEM30A Proteins for Mus musculus (Mouse)

TMEM30A Proteins for Homo sapiens (Human)