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TPBG

TPBG,即滋養(yǎng)層糖蛋白,別名5T4和WAIF1。它是一種由TPBG基因編碼的跨膜糖蛋白,首次在人胎盤組織中發(fā)現(xiàn)。TPBG在多種癌細(xì)胞中過度表達(dá),與腫瘤的侵襲、轉(zhuǎn)移和預(yù)后密切相關(guān)。其作用機(jī)制涉及作為Wnt/β-catenin信號通路的拮抗劑,通過抑制LRP6與Wnt受體的內(nèi)吞來阻斷信號傳導(dǎo),從而抑制細(xì)胞粘附和細(xì)胞骨架的形成,促進(jìn)腫瘤細(xì)胞的遷移和擴(kuò)散。TPBG的異常表達(dá)與多種癌癥的發(fā)展有關(guān),使其成為腫瘤治療的潛在靶點(diǎn),靶向TPBG的藥物開發(fā)正在積極探索中。

熱銷產(chǎn)品

Recombinant Human Trophoblast glycoprotein (TPBG), partial (Active) (CSB-MP024093HUb0)

驗(yàn)證數(shù)據(jù)

CSB-MP024093HUb0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP024093HUb0

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TPBG at 2 μg/mL can bind Anti-TPBG recombinant antibody (CSB-RA024093MA1HU), the EC50 is 1.230-1.519 ng/mL.

TPBG Recombinant Monoclonal Antibody (CSB-RA024093MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA024093MA1HU

The Binding Activity of TPBG with Anti-TPBG monoclonal antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TPBG (CSB-MP024093HUB0) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.230-1.519 ng/mL.

CSB-RA024093MA1HU

The Binding Activity of Macaca fascicularis TPBG with Anti-TPBG monoclonal antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis TPBG (CSB-MP024093MOV) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.672-2.181 ng/mL.

TPBG Antibodies

TPBG for Rattus norvegicus (Rat)

TPBG for Homo sapiens (Human)

TPBG Proteins

TPBG Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

TPBG Proteins for Rattus norvegicus (Rat)

TPBG Proteins for Homo sapiens (Human)



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