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TSHR

促甲狀腺激素受體(TSHR)是一種位于甲狀腺濾泡細胞膜上的糖蛋白受體,全稱為甲狀腺刺激素受體。它負責感知促甲狀腺激素(TSH)或自身抗體的結合,從而調控甲狀腺激素(T3/T4)的合成與分泌。TSHR通過復雜的信號網絡,在人體代謝、生長發育和能量平衡中發揮核心作用。近年來,TSHR被證實與多種自身免疫性甲狀腺疾病及甲狀腺癌密切相關,使其成為生物醫藥領域的研究熱點。
TSHR的異常激活或失調與多種疾病有關。例如,Graves病患者體內產生自身抗體激活TSHR,導致甲狀腺激素過量分泌和甲亢,并可能發展為Graves眼病,引起眼部肌肉腫脹。與之相反,橋本甲狀腺炎患者體內存在阻斷性抗體,抑制TSHR功能并引發甲狀腺功能減退。此外,約80%的分化型甲狀腺癌呈現TSHR過度表達,通過激活MAPK和PI3K/AKT通路促進腫瘤增殖及轉移。基于TSHR的分子特性,放射性碘治療已成功應用于甲狀腺癌靶向治療。
針對TSHR功能異常引發的疾病,已形成多維度靶向治療格局。例如,CAR-T細胞療法通過基因工程改造T細胞靶向TSHR,實現特異性殺傷;重組TSHR類藥物如Thyrogen可增強甲狀腺細胞攝碘能力,賽諾璟提升rhTSH半衰期,提高術后清甲成功率;單/雙抗藥物如GensSci098單抗降低游離T4水平并抑制眼眶成纖維細胞IL-6分泌,雙抗藥物VBS-102創新性構建TSHR和IGF-1R雙靶點阻斷機制,抑制多條通路活性,改善眼球突出。融合蛋白與基因療法如VTC-G90降低甲狀腺激素水平,基因編輯療法縮小甲狀腺體積,為治療甲狀腺相關疾病提供了新的方向。

熱銷產品

Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) (CSB-MP025131HU)

驗證數據

CSB-MP025131HU

CSB-MP025131HU is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP025131HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TSHR at 10 μg/ml can bind Anti-TSHR recombinant antibody (CSB-RA025131MA1HU). The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.

CSB-MP025131HU

The purity of VLPs was greater than 90% as determined by SEC-HPLC

Recombinant Human Thyrotropin receptor (TSHR), partial (CSB-BP025131HU1)

驗證數據

CSB-BP025131HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TSHR Recombinant Monoclonal Antibody (CSB-RA025131MA1HU)

驗證數據

CSB-RA025131MA1HU

The Binding Activity of Human TSHR with Anti-TSHR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSHR (CSB-MP025131HU) at 10 μg/mL can bind Anti-TSHR recombinant antibody. The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.

CSB-RA025131MA1HU

Untransfected HEK293T cells (green line) and transfected Human TSHR HEK293T stable cells (red line) were stained with anti-TSHR antibody (CSB-RA025131MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA025131MA1HU

The purity of TSHR was greater than 95% as determined by SEC-HPLC

TSHR Antibodies

TSHR for Homo sapiens (Human)

TSHR Proteins

TSHR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

TSHR Proteins for Rattus norvegicus (Rat)

TSHR Proteins for Mus musculus (Mouse)

TSHR Proteins for Ovis aries (Sheep)

TSHR Proteins for Bos taurus (Bovine)

TSHR Proteins for Sus scrofa (Pig)

TSHR Proteins for Felis catus (Cat) (Felis silvestris catus)

TSHR Proteins for Homo sapiens (Human)