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TTI1

TELO2-interacting protein 1 homolog is a protein in humans that is encoded by TTI1 gene. Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

TTI1 Antibodies

TTI1 for Homo sapiens (Human)

TTI1 Proteins

TTI1 Proteins for Homo sapiens (Human)

TTI1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

TTI1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

TTI1 Proteins for Mus musculus (Mouse)