VAV1
VAV1，即Vav鳥嘌呤核苷酸交換因子1，別名VAV，是一種信號轉(zhuǎn)導(dǎo)蛋白，屬于Vav家族成員之一。VAV1主要在造血細(xì)胞中表達(dá)，包括T細(xì)胞、B細(xì)胞、單核細(xì)胞、自然殺傷(NK)細(xì)胞、粒細(xì)胞和樹突狀細(xì)胞。
VAV1的作用機(jī)制涉及作為Rho亞家族GTP酶的磷酸化依賴性的GDP/GTP交換因子(GEF)，激活導(dǎo)致肌動蛋白細(xì)胞骨架重新排列和轉(zhuǎn)錄改變的信號通路。
VAV1在T細(xì)胞和B細(xì)胞的發(fā)育和激活中發(fā)揮重要作用，參與免疫細(xì)胞生長、增殖、轉(zhuǎn)化和遷移的調(diào)節(jié)。VAV1對T細(xì)胞受體激活的反應(yīng)強(qiáng)度有重要影響，特別是鈣離子參與的激活轉(zhuǎn)錄因子等事件。
VAV1的異常表達(dá)與多種疾病相關(guān)，包括自身免疫性疾病和腫瘤惡化，使其成為治療和干預(yù)癌癥的潛在靶點。
熱銷產(chǎn)品
驗證數(shù)據(jù)
Western Blot analysis of Jurkat cells using Vav1 Polyclonal Antibody
VAV1 Antibodies
VAV1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025803GA01HU | VAV1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA282857 | Phospho-VAV1 (Tyr174) Antibody | Human,Rat | ELISA,WB |
| CSB-PA262057 | VAV1 (Ab-174) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA918051 | VAV1 (Ab-174) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA004438 | VAV1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA004653 | VAV1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA060050 | Phospho-VAV1 (Y174) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA060053 | Phospho-VAV1 (Y174) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA060056 | VAV1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA010557 | Phospho-VAV1 (Y160) Antibody | Human,Mouse,Rat | IHC, ELISA |
VAV1 Proteins
VAV1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025803HU CSB-EP025803HU CSB-BP025803HU CSB-MP025803HU CSB-EP025803HU-B |
Recombinant Human Proto-oncogene vav (VAV1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VAV1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025803MO CSB-EP025803MO CSB-BP025803MO CSB-MP025803MO CSB-EP025803MO-B |
Recombinant Mouse Proto-oncogene vav (Vav1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VAV1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025803RA CSB-EP025803RA CSB-BP025803RA CSB-MP025803RA CSB-EP025803RA-B |
Recombinant Rat Proto-oncogene vav (Vav1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
