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XRCC5

X-ray repair cross-complementing protein 5 is a protein in humans that is encoded by XRCC5 gene. Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.

XRCC5 Antibodies

XRCC5 for Homo sapiens (Human)

XRCC5 Proteins

XRCC5 Proteins for Homo sapiens (Human)

XRCC5 Proteins for Mus musculus (Mouse)