Rat kininogen(KNG) ELISA Kit

文獻引用 (1) 說明書下載

產(chǎn)品詳情

產(chǎn)品描述：

大鼠激肽原(KNG)酶聯(lián)免疫試劑盒（CSB-E12725r）為雙抗夾心法ELISA試劑盒，定量檢測樣本中的KNG1含量。KNG1 即激肽原 1，是血漿中產(chǎn)生激肽的前體蛋白。它是多種蛋白水解酶的作用底物，在緩激肽生成、凝血啟動等生理過程中發(fā)揮重要作用。對 KNG1 的研究有助于深入了解相關疾病發(fā)病機制，并為開發(fā)新的治療靶點和藥物提供思路。該產(chǎn)品適用于大鼠生物樣本中KNG蛋白表達的科研檢測，可支持高血壓病理模型構建、炎癥信號通路解析、藥物干預效應評估等基礎研究，為探索激肽系統(tǒng)在生理及疾病中的分子機制提供高效工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

Kng1 ELISA Kit; Kng ELISA Kit; Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain] ELISA Kit
縮寫：

KNG1
Uniprot No.：

P08934
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

0.39 ng/ml-25 ng/ml
靈敏度：

0.097 ng/ml
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Cardiovascular
測定原理：

quantitative
測定方法：

Sandwich
數(shù)據(jù)處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

功能：

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
基因功能參考文獻：
1. High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury. PMID: 17293494
亞細胞定位：

Secreted, extracellular space.
組織特異性：

Plasma.
數(shù)據(jù)庫鏈接：

KEGG: rno:25087

STRING: 10116.ENSRNOP00000065146

UniGene: Rn.128333