ABAT
ABAT，全稱為γ-氨基丁酸轉(zhuǎn)氨酶，也常被簡(jiǎn)稱為GABA-T。它是維持神經(jīng)系統(tǒng)穩(wěn)定的重要分子，主要參與抑制性神經(jīng)遞質(zhì)γ-氨基丁酸的代謝過(guò)程，通過(guò)促進(jìn)該遞質(zhì)的分解來(lái)調(diào)控其在體內(nèi)的濃度平衡。當(dāng)ABAT功能異常時(shí)，γ-氨基丁酸的代謝會(huì)出現(xiàn)紊亂，可能引發(fā)一系列神經(jīng)系統(tǒng)疾病，其中較為典型的是遺傳性GABA轉(zhuǎn)氨酶缺乏癥，患者多在嬰幼兒階段發(fā)病，表現(xiàn)為頻繁癲癇發(fā)作、智力發(fā)育遲緩等癥狀。在臨床治療領(lǐng)域，針對(duì)該蛋白的藥物已得到應(yīng)用，比如氨己烯酸，它能降低這個(gè)蛋白的活性，從而提升體內(nèi)γ-氨基丁酸的水平，幫助緩解癲癇發(fā)作，目前已成為嬰兒痙攣癥等難治性癲癇的重要治療藥物之一。
熱銷產(chǎn)品
Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) (CSB-EP001032HUe0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ABAT Recombinant Monoclonal Antibody (CSB-RA242969A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA242969A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
ABAT Antibody (CSB-PA001032ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: 4-aminobutyrate aminotransferase, mitochondrial antibody at 10μg/ml
Lane 1: Rat liver tissue
Lane 2: Mouse pancreatic tissue
Lane 3: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56 kDa
Observed band size: 56 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001032ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA001032ESR1HU at dilution of 1:100
ABAT Antibodies
ABAT for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001032GA01HU | ABAT Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001032ESR1HU | ABAT Antibody | Human, Mouse, Rat | ELISA, WB, IHC |
| CSB-RA242969A0HU | ABAT Recombinant Monoclonal Antibody | Human | ELISA, IHC |
ABAT Proteins
ABAT Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001032HU CSB-BP001032HU CSB-MP001032HU CSB-EP001032HU-B |
Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001032HU | Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) | E.coli |
| CSB-EP001032HUe0 | Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT) | E.coli |
