JAK1，即酪氨酸激酶2亞家族成員1，別名Janus kinase 1。JAK1是一種非受體型酪氨酸激酶，屬于Janus激酶家族，廣泛參與細(xì)胞內(nèi)信號(hào)傳導(dǎo)。它由人體細(xì)胞自身的基因編碼，在多種細(xì)胞類型中都有表達(dá)。JAK1的作用機(jī)制主要通過與細(xì)胞表面受體的胞內(nèi)部分相互作用，當(dāng)這些受體被相應(yīng)配體激活時(shí)，JAK1被招募并激活，進(jìn)而通過自身磷酸化和磷酸化受體的酪氨酸殘基，為信號(hào)轉(zhuǎn)導(dǎo)分子提供結(jié)合位點(diǎn)，從而啟動(dòng)下游信號(hào)通路。JAK1在生物學(xué)上的意義非常重大，它參與了多種細(xì)胞信號(hào)傳導(dǎo)過程，包括細(xì)胞增殖、分化、凋亡以及免疫反應(yīng)等。JAK1與多種細(xì)胞因子受體相關(guān)聯(lián)，如干擾素、生長(zhǎng)因子和激素受體等，通過激活這些受體的信號(hào)傳導(dǎo)，JAK1參與調(diào)控了STAT（信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子）蛋白的磷酸化和核轉(zhuǎn)位，從而影響基因表達(dá)。JAK1的功能異常與多種疾病有關(guān)，尤其是自身免疫性疾病和癌癥，因此，JAK1抑制劑的開發(fā)已成為治療這些疾病的新策略。

熱銷產(chǎn)品

Recombinant Human Tyrosine-protein kinase JAK1 (JAK1), partial (CSB-YP011930HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

JAK1 Recombinant Monoclonal Antibody (CSB-RA227790A0HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA227790A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.