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PECAM1

血小板內皮細胞黏附分子-1(PECAM1)又稱CD31或EndoCAM,是一種跨膜糖蛋白,主要表達于血管內皮細胞、血小板及部分免疫細胞表面。PECAM1通過同源或異源分子結合介導細胞間黏附,參與調控血管通透性、炎癥反應中白細胞的跨內皮遷移以及血管生成過程。其胞內段酪氨酸殘基磷酸化后可激活下游信號,與PI3K/AKT、MAPK等通路存在關聯,在維持血管穩態中起關鍵作用。
PECAM1異常表達與動脈粥樣硬化斑塊形成、血栓性疾病及腫瘤血管生成密切相關。在動脈粥樣硬化中,其介導的單核細胞浸潤加速斑塊進展;在腫瘤微環境中則可能通過調控血管新生促進癌癥轉移。目前針對PECAM1的治療策略多處于臨床前階段,包括開發阻斷其介導白細胞遷移的單克隆抗體,以及利用其作為靶點構建腫瘤血管靶向藥物遞送系統。

熱銷產品

PECAM1 Recombinant Monoclonal Antibody (CSB-RA017767MA1HU)

驗證數據

CSB-RA017767MA1HU

Western Blot
Positive WB detected in: THP-1 whole cell lysate, JK whole cell lysate
All lanes: PECAM1 antibody at 1:500
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 82-140 kDa
Observed band size: 140 kDa

CSB-RA017767MA1HU

Overlay Peak curve showing THP-1 cells stained with CSB-RA017767MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human soluble platelet endothelial cell adhesion molecule 1,sPECAM-1 ELISA Kit (CSB-E08133h)

驗證數據

CSB-E08133h 標準曲線

貨號:CSB-E08133h

規格:96T/48T

靈敏度:7.8 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PECAM1 Antibodies

PECAM1 for Homo sapiens (Human)

PECAM1 Proteins

PECAM1 Proteins for Bos taurus (Bovine)

PECAM1 Proteins for Homo sapiens (Human)

PECAM1 Proteins for Rattus norvegicus (Rat)

PECAM1 Proteins for Sus scrofa (Pig)

PECAM1 ELISA Kit

PECAM1 ELISA Kit for Mus musculus (Mouse)

PECAM1 ELISA Kit for Rattus norvegicus (Rat)

PECAM1 ELISA Kit for Homo sapiens (Human)



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